منابع مشابه
How to prepare a chiral Grignard reagent: a theoretical proposal.
It is shown that two competitive pathways (T2 vs T4) exist for Grignard reagent formation. While the nonradical pathway T2 leads to retention of the configuration, the radical pathway T4 gives racemization. Our calculations suggest the way that T2 can be enhanced, which should be of significance to prompt new synthesis approaches for the preparation of chiral Grignard reagents.
متن کاملRadical isomerization during Grignard reagent formation. A quantitative treatment.
( l ) (a) Walborsky, H.M.; Young, A. E. J. Am. Chem. Soc. 1961,83, 2595. (b) Walborsky, H. M.; Young, A. E. J. Am. Chem. Soc. 1964, 86,3288. (c) Wafborsky, H. M.; Aronoff, M. S. "/. Organomet. Chem. 1973, 5i,,31. (d) Walborsky, H. M.; Banks, R. B. Bul / . Soc. Chim. Belg.1980,89,849. (2) Ruchardt , C. ; Trautwein, H. Chem. Ber. 1962,95, 1197. (3) Patel , D. J. ;Hami l ton, C. L. ;Roberts, J.D. ...
متن کاملDi-μ-bromido-bis[(diethyl ether-κO)(2,4,6-trimethylphenyl)magnesium]: the mesityl Grignard reagent
The crystal structure of the title compound, [Mg2Br2(C9H11)2(C4H10O)2], features a centrosymmetric two-centre magnesium complex with half a mol-ecule in the asymmetric unit. The Mg atom is in a considerably distorted Br2CO coordination. Bond lengths and angles are comparable with already published values. The crystal packing is stabilized by C-H⋯π inter-actions linking the complexes into sheets...
متن کاملCorrection: progress and developments in the turbo Grignard reagent i-PrMgCl·LiCl: a ten-year journey.
There are two errors in Scheme 32 on page 6987. The first is that the substituted phenylmagnesium bromide-lithium chloride complex reagent (left) should be substituted pyridylmagenesium bromide-lithium chloride in the synthesis of GSK 269984B in the middle of Scheme 32. The structure should appear as follows: The second error, in the last row of Scheme 32 is that the structures of the fluoroqui...
متن کاملPhotochemical grafting of methyl groups on a Si(111) surface using a Grignard reagent.
The photochemical grafting of methyl groups onto an n-type Si(111) substrate was successfully achieved using a Grignard reagent. The preparation involved illuminating a hydrogen-terminated Si(111) that was immersed in a CH3MgBr-THF solution. The success was attributed to the ability of the n-type hydrogenated substrate to produce holes on its surface when illuminated. The rate of grafting methy...
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ژورنال
عنوان ژورنال: Nature
سال: 1950
ISSN: 0028-0836,1476-4687
DOI: 10.1038/165485a0